In Vitro Anti-Inflammatory Activity of Bajakah Tampala Root (Spatholobus littoralis Hassk.)

Penulis

  • Sri Karina Maskur Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia
  • Masdiana Tahir Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia
  • Rais Razak Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia

DOI:

https://doi.org/10.33096/pharmrep.v4i1.358

Kata Kunci:

Bajakah tampala root, extract, anti-inflammatory, protein denaturation

Abstrak

Bajakah tampala root (Spatholobus littoralis Hassk.) contains phenolic compounds, flavonoids, tannins, terpenoids and saponins. Flavonoid compounds have pharmacological effects, namely anti-inflammatory. The purpose of this study was to determine the anti-inflammatory activity of ethanol extract of bajakah tampala root by inhibiting protein denaturation in vitro using UV-Vis spectrophotometer and diclofenac sodium as positive control. The extract was prepared by maceration method using 96% ethanol solvent. The results showed that the ethanol extract of bajakah tampala root had a percentage of inhibition of 31.27% at the lowest concentration (10 ppm) and 43.28% at the highest concentration (50 ppm) with an IC50 value of 77.92 µg/mL and the ic50 value of diclofenac sodium is 12.26 µg/mL. The percentage of inhibition that is more than 20% is considered to have inhibitory power in the protein denaturation process. So, it can be concluded that the ethanol extract of bajakah root has potential as an anti-inflammatory.

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Unduhan

Diterbitkan

2025-07-22

Terbitan

Vol 4 No 1 (2025): (March) Pharmaceutical Reports

Bagian

Articles

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