Modulation Imaging Contrast Agent for Cancer

Muammar Fawwaz

Abstract


Molecular imaging, also known as molecular imaging, is a medical technique used to visualize and analyze biological molecules in the human or animal body. According to the Society of Nuclear Medicine and Molecular Imaging's website, "Molecular Imaging" is a type of medical imaging that provides a detailed picture of what is happening in the body at the molecular and cellular levels. This definition refers to the significant advancements researchers have made over the past two decades in applying the principles of molecular imaging in various areas, from basic and translational science to advanced patient diagnosis and therapy. Essentially, molecular imaging allows us to visualize biochemical processes and target localization patterns that are invisible at the level of anatomical imaging. The goal of molecular imaging is to obtain information about molecular activity and function in living tissue. The technologies commonly used in imaging modulation are Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).

Keywords


Contrast agent; MRI; PET; Probes; SPECT

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References


Lindner, J. R., and Link, J. Molecular Imaging in Drug Discovery and Development. Circ Cardiovasc Imaging, 2018; 11(2): e005355.

Berger, A. Magnetic resonance imaging. Bmj, 2002; 324(7328): 35.

Crișan, G., Moldovean-Cioroianu, N. S., Timaru, D. G., Andrieș, G., Căinap, C., & Chiș, V. Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade. Int J Mol Sci, 2022; 23(9).

Dhoundiyal, S., Srivastava, S., Kumar, S., Singh, G., Ashique, S., Pal, R., Mishra, N., & Taghizadeh-Hesary, F. Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation. Eur J Med Res, 2024; 29(1): 26.

Fawwaz, M., Mishiro, K., Nishii, R., Sawazaki, I., Shiba, K., Kinuya, S., & Ogawa, K. Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR). Molecules, 2020; 25(12).

Glunde, K., Artemov, D., Penet, M. F., Jacobs, M. A., & Bhujwalla, Z. M. Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. Chem Rev, 2010; 110(5): 3043-3059.

Glunde, K., Jiang, L., Moestue, S. A., & Gribbestad, I. S. MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR Biomed, 2011; 24(6): 673-690.

Gomes Marin, J. F., Nunes, R. F., Coutinho, A. M., Zaniboni, E. C., Costa, L. B., Barbosa, F. G., Queiroz, M. A., Cerri, G. G., & Buchpiguel, C. A. Theranostics in Nuclear Medicine: Emerging and Re-emerging Integrated Imaging and Therapies in the Era of Precision Oncology. RadioGraphics, 2020; 40(6): 1715-1740.

Grover, V. P., Tognarelli, J. M., Crossey, M. M., Cox, I. J., Taylor-Robinson, S. D., & McPhail, M. J. Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians. J Clin Exp Hepatol, 2015; 5(3): 246-255.

Jarritt, P. H., & Acton, P. D. PET imaging using gamma camera systems: a review. Nucl Med Commun, 1996; 17(9): 758-766.

Jødal, L., Afzelius, P., Alstrup, A. K. O., & Jensen, S. B. Radiotracers for Bone Marrow Infection Imaging. Molecules, 2021; 26(11).

Khalil, M. M., Tremoleda, J. L., Bayomy, T. B., & Gsell, W. Molecular SPECT Imaging: An Overview. Int J Mol Imaging, 2011; 796025.

Li, Z., Bai, R., Yi, J., Zhou, H., Xian, J., & Chen, C. Designing Smart Iron Oxide Nanoparticles for MR Imaging of Tumors. Chem Biomed Imaging, 2023; 1(4): 315-339.

Lindner, J. R., & Link, J. Molecular Imaging in Drug Discovery and Development. Circ Cardiovasc Imaging, 2018; 11(2): e005355.

Ogawa, K., Ono, M., Tian, M., Ueda, M., & Higuchi, T. Development of radiolabeled compounds for molecular imaging and imaging-based therapy. ScientificWorldJournal, 2015; 365418.

Petralia, G., Zugni, F., Summers, P. E., Colombo, A., Pricolo, P., Grazioli, L., Colagrande, S., Giovagnoni, A., & Padhani, A. R. Whole-body magnetic resonance imaging (WB-MRI) for cancer screening: recommendations for use. Radiol Med, 2021; 126(11): 1434-1450.

Rahman, M. Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine. Nanotheranostics, 2023; 7(4): 424-449.

Rinne, S. S., Orlova, A., & Tolmachev, V. PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology. Int J Mol Sci, 2021; 22(7).

Rong, J., Haider, A., Jeppesen, T. E., Josephson, L., & Liang, S. H. Radiochemistry for positron emission tomography. Nature Communications, 2023; 14(1): 3257.

Rowe, S. P., & Pomper, M. G. Molecular imaging in oncology: Current impact and future directions. CA: A Cancer Journal for Clinicians, 2022; 72(4): 333-352.

Salmanoglu, E., Kim, S., & Thakur, M. L. Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail. Semin Nucl Med, 2018; 48(2): 86-99.

Seaman, M. E., Contino, G., Bardeesy, N., & Kelly, K. A. Molecular imaging agents: impact on diagnosis and therapeutics in oncology. Expert Rev Mol Med, 2010; 12 e20.

Sivasubramanian, M., Chu, C. H., Cheng, S. H., Chen, N. T., Chen, C. T., Chuang, Y. C., Yu, H., Chen, Y. L., Liao, L. D., & Lo, L. W. Multimodal Magnetic Resonance and Photoacoustic Imaging of Tumor-Specific Enzyme-Responsive Hybrid Nanoparticles for Oxygen Modulation. Front Bioeng Biotechnol, 2022; 10: 910902.

Valotassiou, V., Leondi, A., Angelidis, G., Psimadas, D., & Georgoulias, P. SPECT and PET imaging of meningiomas. Scientific World Journal, 2012; 412580.

Zhu, A., Lee, D., & Shim, H. Metabolic positron emission tomography imaging in cancer detection and therapy response. Semin Oncol, 2011; 38(1): 55-69.




DOI: https://doi.org/10.33096/pharmrep.v3i1.283

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