Determination of Acetaminophen in Jamu Pegal Linu by High Performance Liquid Chromatography

Authors

  • Mamat Pratama Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar
  • Dian Harisman Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar
  • Lukman Labasy Department of Pharmacy, STIKES Maluku Husada, West Seram, Maluku
  • Seniwati Seniwati Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Hasanuddin
  • Muammar Fawwaz Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar

DOI:

https://doi.org/10.33096/pharmrep.v1i1.154

Keywords:

Traditional medicine, jamu pegal linu, acetaminophen, High Performance Liquid Chromatography

Abstract

Traditional medicine is very popular in Indonesia, so it is necessary to do this research to analyze the presence or absence of chemical substances contained in traditional medicine. This research aims to determine acetaminophen content on jamu pegal linu circulating in Makassar city by High Performance Liquid Chromatography (HPLC). The jamu were obtained from several drugs stores near Terong traditional market. Five brands of jamu pegal linu detected their acetaminophen content by HPLC method using a UV-Visible SPD 20A detector with a wavelength of 254 nm. The result showed that chromatogram on jamu pegal linu is the same as the acetaminophen at the retention time of 5.28 minutes. The whole of jamu pegal linu analyzed positively contain acetaminophen and prohibited for consumption in accordance with the regulations of National Agency of Drug and Food Control (POM) Republic Indonesia No.KH.00.01.43.2773/2008.

References

Abebe W. Herbal Medication: Potential for Adverse Interactions with Analgesic Drugs. J Clin Pharm Ther. 2002; 27: 391-401.

Akerele O. Natures Medicinal Bounty: Don’t Throw It Away. World Health Forum. 1993; 14: 390–395.

Banureah EM. Thesis of master’s degree. Metampiron Content Analysis on Traditional Herbal in Medan City, Universitas Sumatra Utara, Indonesia. 2009.

Chan K. Some Aspects of Toxic Contaminants in Herbal Medicines. Chemosphere. 2003; 52:1361–1371.

Ditjen POM R.I. Catalog of Traditional Medicines and Food Supplements. National Agency of Drug and Food Control, Indonesia, 2004.

Fawwaz M and Baits M. Chemical Hydrolysis of Soybean (Glycine max (L.) Merill) to Get Genistein Compound. Int J PharmTech. Res. 2016; 9(4): 340-343.

Fawwaz M, Labasy L, Saleh A, Mandati SS and Pratama M. Determination of mercury (Hg) and lead (Pb) content in selected milkfish from fishponds around Pampang – Makassar River. Int Food Res J. 2019; 26(2): 689-693.

Firdaus MI and Utami PI. Qualitative Analysis of Paracetamol on Herbal Pegal Linu Circulating in Purwokerto. Pharmacy. 2009; 6(2): 1-5.

Handayani L. Utilization of Traditional Medicines in Handling Health Problems. Indo Med Mag, 2001; 51(3): 139-144.

Hussin AH. Adverse Effects of Herbs and Drug-Herbal Interactions. Malays J Pharm Sci. 2001; 1(2): 39-44.

Nasution YA. Thesis of master’s degree. Determination of Paracetamol Active Substance in Oral Dosage Drugs with High Performance Liquid Chromatography (HPLC) Method, Universitas Sumatera Utara, Indonesia, 2009.

Naid T, Kasim S and Pakaya M. Determination of Paracetamol Levels in Tablet Combination of Paracetamol with Caffeine by UV-Visible Spectrophotometry. Universitas Hasanuddin, Indonesia, 2011, pp. 77–82.

Sarigih ATW, Kusuma AM and Utami PI. Analysis of Sildenafil Citrate in Traditional Herbal Medicine Strong Men A and B by High Performance Liquid Chromatography Method. Pharmacy. 2010; 7(1): 1-5.

Wahyuni AS and Sujono TA. Study Activity of Analgesic Effect in Jamu Pegal Linu. J Sci Tech Res. 2004; 5(1): 21-32

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Published

2022-05-15

Issue

Vol. 1 No. 1 (2022): (March) Pharmaceutical Reports

Section

Articles

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