Evaluation of the Anti-Inflammatory Effect of Ethanol Extract of Porang Tuber (Amorphophallus muelleri Blume) on White Rats (Rattus norvegicus)
DOI:
https://doi.org/10.33096/pharmrep.v5i1.395Kata Kunci:
Anti-inflammatory, extraction, phytochemical, spectrophotometry, protectiveAbstrak
Inflammation is a protective response to tissue injury aimed at neutralizing or eliminating invasive organisms triggered by physical trauma. One of the plants known for its anti-inflammatory properties is the porang tuber, which contains flavonoids. This study aimed to determine the anti-inflammatory effect and effective dosage of ethanol extract of porang tuber (Amorphophallus muelleri Blume) in male rats (Rattus norvegicus). An experimental design was employed, utilizing 20 white rats divided into five treatment groups: a negative control (1% NaCMC), a positive control (sodium diclofenac), and porang tuber ethanol extract at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW. Test preparations were administered one hour before the induction of 1% carrageenan (0.1 mL, intraplantar). Paw edema volume was measured plethysmographically every 60 minutes for 6 hours. Statistical analysis, performed via one-way ANOVA followed by a Bonferroni post-hoc test, revealed no significant difference between the positive control group and the porang tuber ethanol extract groups. In conclusion, the porang tuber ethanol extract exhibits anti-inflammatory effects, with a dose of 400 mg/kgBW identified as the most effective.
Referensi
Aryanti, N., Abidin, K.Y. Ekstraksi glukomanan dari porang lokal (Amorphophallus oncophyllus dan Amorphophallus muerelli Blume). Metana. 2015; 11(01): 21-30.
Dermiati, T., Kamal, A., Tibe, F., Anggi, V. Uji antiinflamasi ekstrak etanol kulit batang ceremai (Phyllanthus acidus L. Skell) terhadap edema kaki tikus. Farmakologi Jurnal Farmasi. 2018; 15(1): 1-8.
Emelda, E., Nugraeni, R., Damayanti, K. Review: Exploration of Indonesian herbal plants for anti-inflammatory. Inpharnmed Journal (Indonesian Pharmacy and Natural Medicine Journal). 2023; 6(2): 58-64.
Fawwaz, M., Purwono, B., Sidiq, Y., Arwansyah, Arsul, M. I., Fitriana & Baits, M. Anti‐inflammatory, Antioxidant, and Antibacterial Activities with Molecular Docking Studies of Vitex Trifolia L. Targeting Human COX‐2 and Peroxiredoxin‐ 5. ChemistrySelect, 2024; 9(39), e202403834.
Goodman, L.S., Gilman, A. The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw-Hill, 2012.
Hartaman, N.R., Abidin, Z., Dahlia, A.A. Aktivitas antioksidan ekstrak etanol umbi porang (Amorphophallus oncophyllus) dengan
metode ekstraksi ultrasonik. Makassar Natural Product Journal. 2023; 1: 155-163.
Idacahyati, K., Nofianti, T., Aswa, G.A., Nurfatwa, M. Hubungan tingkat kejadian efek samping antiinflamasi non-steroid dengan usia
dan jenis kelamin. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia. 2019; 6(2): 56-61.
Katzung, B.G., Masters, S.B., Trevor, A. Farmakologi Dasar & Klinik Edisi 12. Penerbit Buku Kedokteran EGC, Jakarta 2014. Kemenkes RI. Laporan Nasional Riskesdas 2018, Terbit 2019. https://repository.kemkes.go.id/book/1323 (accessed August 10, 2025). Latief, M., Anggun, F., Fisesa, T., Putri, M., Sari, M., Indra, T., et al. Anti-inflammatory activity of sungkai leaves (Peronema
canescens Jack) ethanol extract in carrageenan-induced mice. Jurnal Farmasi Sains dan Praktis. 2021; 7(2): 144-153.
Lestari, M., Handayani, S., Susilo, E., Pujiwati, H. Growth and production of Porang (Amorphophallus muelleri Blume) plant due to sunlight intensity and different plant media formulation. AGRITEPA: Jurnal Ilmu Dan Teknologi Pertanian. 2023; 10(1): 111-122.
Manengkey, SF., Karauwan, FA., Ginting, AR., Tumbel, SL. Uji efektivitas ekstrak bunga pepaya jantan (Carica papaya L.) sebagai analgesik terhadap tikus putih (Rattus norvegicus). The Tropical Journal of Biopharmaceutical. 2020; 3(1): 1-5.
Octavian, I.P. Aktivitas antiinflamasi ekstrak etanol tanaman patah tulang (Euphorbia tirucalli L.). Humantech: Jurnal Ilmiah Multidisiplin Indonesia. 2022; 1(7): 902-908.
Prayitno, S., Juwaeni, A., Asri, A., Uji efektivitas antiinflamasi ekstrak kulit batang jambu mete (Anacardium occidentale) pada hewan uji mencit (Mus musculus). Fito Medicine: Journal Pharmacy and Sciences. 2022; 13(2): 102-110.
Priamsari, M.R., Krismonikawati, R.A. Uji daya antiinflamasi ekstrak etanolik kulit terong belanda (Solanum betaceum Cav.) pada mencit jantan yang diinduksi karagenin. Jurnal Ilmu Farmasi dan Farmasi Klinik. 2020; 16(2): 86-92.
Putri, F.S., Arief, M.J., Rusli, R. Uji aktivitas antiinflamasi akut ekstrak etanol dan ekstrak air daun telang (Clitoria ternatea L.) dengan induksi karagenan. Jurnal Mandala Pharmacon Indonesia. 2024; 10(1): 151-156.
Rahajeng, V.N., Permana, S. Uji efek antiinflamasi ekstrak etanol batang alang-alang (Imperata cylindrica (L.) Beauv) terhadap tikus putih jantan yang diinduksi karagenin. Jurnal Ilmiah Bakti Farmasi. 2020; 5(1): 37-44.
Sriarumtias, F.F., Ardian, M.E., Najihudin, A. Uji aktivitas ekstrak daun jeruk manis (Citrus × aurantium L.) sebagai antiinflamasi. Pharmacy: Jurnal Farmasi Indonesia. 2020; 17(1): 197-206.
TMNQ, Translation of The Meanings of The Noble Qur’an: Hilali and Khan (Surah Fāṭir [35]:9). https://quranenc.com/en/browse/english_hilali_khan/35 (accessed August 10, 2025).
Wardani, I.G.A.A.K. Efektivitas gel ekstrak bunga kecombrang (Etlingera elatior) sebagai antiinflamasi terhadap mencit yang diinduksi karagenan. Jurnal Ilmiah Medicamento. 2020; 6(1): 66-71.
Wasiaturrahmah, Y., Amalia, N. Potensi antiinflamasi ekstrak daun kecapi sentul (Sandoricum koetjape Merr) dengan metode stabilisasi membran sel darah merah. JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi dan Kesehatan. 2023; 8(1): 125-133.
Yasacaxena, P.L., Defi, M.N., Kandari, V.P., Weru, P.T., Papilaya, F., Oktafera, M., et al. Ekstraksi Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dan Aktivitas Sebagai Antibakteri. Jurnal Jamu Indonesia. 2023; 8(1): 10-17.
Zunnita, O., Auliya, R. Uji efektivitas antiinflamasi ekstrak daun jamblang (Syzygium cumini L.) terhadap mencit (Mus musculus L.) yang diinduksi karagenan. Jurnal Ilmu Kefarmasian. 2024; 17(1): 1-8.
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